| CBME Curriculum AMCH | ||||
| Community Medicine Phase I MBBS Lesson Plan | ||||
| Topic No. | Lec.No. | Comp. No. | Titles: Topic, Competency with SLO & Lesson | Teaching Methodology |
| 1 | Topic: Basic Biochemistry | |||
| BI1.1 | Describe the
molecular and functional organization of a cell and its sub- cellular components. |
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| BI1.1
/ SLO 1. Cell Composition 2. Subcellular organelles 3. Fluid Mosaic Model 4. Transport mechanisms |
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| 1 | Cell and its Organelles | Lecture | ||
| 2 | Cell Transport Mechanism | Lecture | ||
| 3 | Marker Enzymes | SDL | ||
| 4 | Ultracentrifugation | SGT | ||
| BI11.1 | Describe
commonly used laboratory apparatus and equipments, good safe laboratory practice and waste disposal. |
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| BI1.1
/ SLO 1. Glass ware 2. Pipettes 3. laboratory safety practice |
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| 5,6 | Demonstration of Laboratory Equipments & Glasswares | Practical | ||
| BI11.6 | Describe the principles of colorimetry | |||
| BI11.6
/ SLO 1. Introduction 2. Principle 3. Applications |
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| 7 | Colorimetry | Lecture | ||
| 2 | Topic: Enzyme | |||
| BI2.1 | Explain
fundamental concepts of enzyme, isoenzyme, alloenzyme, coenzyme & co-factors. Enumerate the main classes of IUBMB nomenclature. |
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| BI2.1
/ SLO 1. Definition 2. Classification 3. Co-enzymes |
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| 8 | Enzyme Classification | Lecture | ||
| BI2.2 | Observe the estimation of SGOT & SGPT | |||
| BI2.2
/ SLO 1. Principle 2. Method and Procedure 3. Interpretation |
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| 9,10 | Demonstration of estimation of SGOT & SGPT | Practical | ||
| BI2.3 | Describe
and explain the basic principles of enzyme activity |
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| BI2.3
/ SLO 1. Mode of Action 2. Factors Influencing Enzyme Activity 3. Specificity of Enzymes |
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| 11 | Enzyme Kinetics | Lecture | ||
| BI2.4 | Describe
and discuss enzyme inhibitors as poisons and drugs and as therapeutic enzymes |
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| BI2.4
/ SLO 1. Types of Inhibition 2. Drug Metabolism 3. Regulation of Enzymes Activity 4. Therapeutic use of Enzymes |
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| 12 | Enzyme Inhibition | Lecture | ||
| 13 | Regulation of Enzymes | Lecture | ||
| BI2.5 BI2.6 BI2.7 |
Describe
and discuss the clinical utility of various serum enzymes as markers of pathological conditions. Discuss use of enzymes in laboratory investigations (Enzyme-based assays) Interpret laboratory results of enzyme activities & describe the clinical utility of various enzymes as markers of pathological conditions. |
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| BI2.5,
BI2.6, BI2.7 / SLO 1. Definition of Isoenzymes 2. Enzymes in laboratory investigations 3. Clinical Significance of Various Isoenzymes |
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| 14 | Clinical Enzymology | Lecture | ||
| 15 | Enzyme
in Clinical Diagnosis |
SDL | ||
| 16 | Enzyme Regulation | SGT | ||
| 17 | Enzyme Based Assays | SGT | ||
| 3 | Metabolism and Homeostasis | |||
| BI6.11 BI6.12 BI5.2 |
Describe the
functions of haem in the body and describe the processes involved in its metabolism and describe porphyrin metabolism. Describe the major types of haemoglobin and its derivatives found in the body and their physiological/ pathological relevance. Describe and discuss functions of proteins and structure-function relationships in relevant areas eg, hemoglobin and selected hemoglobinopathies |
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| BI6.11,
BI6.12, BI5.2 / SLO 1. Structure of hemoglobin 2. Oxygen dissociation curve 3. Heme Metabolism 4. Hemoglobin derivatives 5. Hemoglobinopathies 6. Porphyrias 7. Anemia |
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| 18 | Hemoglobin Stucture and Function & Hemoglobinopathies | Lecture | ||
| 19 | Heme Metabolism - Synthesis | Lecture | ||
| 20 | Heme Metabolism - Degradation | Lecture | ||
| 21 | Porphyrias | SGT | ||
| 22 | Biochemical investigations in Anemia | SDL | ||
| 23,24 | Define
and classify hemolytic anemia Describe the etiology, pathogenesis, hematologic indices and peripheral blood picture of Acquired hemolytic anemia |
IT | ||
| BI6.14 BI6.15 BI11.17 |
Describe
the tests that are commonly done in clinical practice to assess the functions of these organs (kidney, liver, thyroid and adrenal glands). Describe the abnormalities of kidney, liver, thyroid and adrenal glands. Explain the basis and rationale of biochemical tests done in the following conditions: - diabetes mellitus, - dyslipidemia, - myocardial infarction, - renal failure, gout, - proteinuria, - nephrotic syndrome, - edema, - jaundice, - liver diseases, pancreatitis, disorders of acid- base balance, - thyroid disorders. |
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| BI6.14,
BI6.15, BI11.17 / SLO 1. Function of Liver 2. Liver diseases 3. Interpretation of Liver Function Test |
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| 25 | Liver Function Test | Lecture | ||
| 26,27 | Describe
& disscuss the Structure and functions of liver and gall bladder |
IT | ||
| 28,29 | Demonstration of heme derivatives | Practical | ||
| 30,31 | Demonstration of SGOT & SGPT estimation | Practical | ||
| 32,33 | Demonstration of Bilirubin estimation | Practical | ||
| 34,35 | Demonstration of ALP estimation | Practical | ||
| BI6.9 BI6.10 |
Describe
the functions of various minerals in the body, their metabolism and homeostasis. Enumerate and describe the disorders associated with mineral metabolism. |
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| BI6.9,
BI6.10 / SLO 1. Sources 2. Functions 3. RDA 4. Disorders |
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| 36 | Mineral Metabolism - Iron | Lecture | ||
| 37 | Mineral Metabolism - Calcium | Lecture | ||
| 38 | Mineral Metabolism - Iodine | Lecture | ||
| 39 | Mineral Metabolism - Copper | Lecture | ||
| 40 | Mineral Metabolism - Other Trace Minerals | Lecture | ||
| 41,42 | Demonstration of Calcium estimation | Practical | ||
| 43,44 | Demonstration of Phosporous estimation | Practical | ||
| BI6.5 | Describe
the biochemical role of vitamins in the body and explain the manifestations of their deficiency |
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| BI6.5
/ SLO 1. Sources 2. Functions 3. RDA 4. Disorders |
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| 45 | Vitamin - A | Lecture | ||
| 46 | Vitamin - D | Lecture | ||
| 47 | Vitamin - E and K | Lecture | ||
| 48 | Vitamin - B1 & B2 | Lecture | ||
| 49 | Vitamin - Niacin | Lecture | ||
| 50 | Vitamin - B6 | Lecture | ||
| 51 | Vitamin - Pantothenic Acid & Biotin, Choline | Lecture | ||
| 52 | Vitamin - Folic Acid | Lecture | ||
| 53 | Vitamin - B12 | Lecture | ||
| 54 | Vitamin - C | Lecture | ||
| 55,56 | Discuss and describe the aetiology, causes, clinical manifestations, complications, diagnosis and management of common vitamin deficiencies | IT | ||
| BI6.7 | Describe
the processes involved in maintenance of normal pH, water & electrolyte balance of body fluids and the derangements associated with these. |
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| BI6.7
/ SLO 1. Fluid Compositions 2. Water Distribution and Balance 3. Body Fluids 4. Electrolyte Distribution and Balance |
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| 57 | Water and Electrolyte Homeostasis | Lecture | ||
| 58 | Water and Electrolyte imbalance | Lecture | ||
| 59,60 | Demonstration of estimation of Electrolytes | Practical | ||
| 4 | Topic: Chemistry and Metabolism of Carbohydrates | |||
| BI3.1 | Discuss and
differentiate monosaccharides, di-saccharides and polysaccharides giving examples of main carbohydrates as energy fuel, structural element and storage in the human body |
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| BI3.1
/ SLO 1. Definition 2. Classification 3. Structure and Properties 4. Reactions of Carbohydrates |
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| 61 | Chemistry of Carbohydrates - Mono & Disaccharids | Lecture | ||
| 62 | Chemistry of Carbohydrates - Polysaccharides | Lecture | ||
| 63,64 | Reactions of Glucose &Fructose | Practical | ||
| 65,66 | Reactions of Sucrose,Maltose & Lactose | Practical | ||
| BI3.2 BI3.3 |
Describe
the processes involved in digestion and assimilation of carbohydrates and storage. Describe and discuss the digestion and assimilation of carbohydrates from food. |
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| BI3.2,
BI3.3 / SLO 1. Mechanism of Digestion 2. Mechanism of Absorption 3. Disorders |
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| 67 | Digestion and Absorption of carbohydrate | Lecture | ||
| BI3.4 BI3.5 |
Define
and differentiate the pathways of carbohydrate metabolism, (glycolysis, gluconeogenesis, glycogen metabolism, HMP shunt). Describe and discuss the regulation, functions and integration of carbohydrate along with associated diseases/disorders. |
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| BI3.4,
BI3.5 / SLO 1. Definition 2. Metabolic Pathway 3. Energetics 4. Regulation 5. Disorders |
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| 68 | Glycolysis and its Regulation | Lecture | ||
| 69 | Gluconeogenesis and Cori Cycle | Lecture | ||
| 70 | Glycogen Metabolism - I | Lecture | ||
| 71 | Glycogen Metabolism - II | Lecture | ||
| 72 | HMP Shunt | Lecture | ||
| 73 | Glycogen Storage disorder | SDL | ||
| BI3.6 BI3.7 |
Describe
and discuss the concept of TCA cycle as a amphibolic pathway and its regulation. Describe the common poisons that inhibit crucial enzymes of carbohydrate metabolism (eg; fluoride, arsenate) |
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| BI3.6,
BI3.7 / SLO 1. Definition 2. Metabolic Pathway 3. Energetics 4. Regulation 5. Disorders |
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| 74 | TCA Cycle and its Regulation | Lecture | ||
| BI3.8 | Discuss
and interpret laboratory results of analytes associated with metabolism of carbohydrates. |
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| BI3.8
/ SLO 1. Definition 2. Metabolic Pathway 3. Disorders |
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| 75 | Glucuronic Acid & Polyol Patway | Lecture | ||
| 76 | Fructose Metabolism | Lecture | ||
| 77 | Galactose Metabolism | Lecture | ||
| 78 | Alcohol Metabolism | Lecture | ||
| 79 | Amino Sugar & Glycoprotein | Lecture | ||
| BI3.9 BI3.10 |
Discuss
the mechanism and significance of blood glucose regulation in health and disease. Interpret the results of blood glucose levels and other laboratory investigations related to disorders of carbohydrate metabolism. |
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| BI3.9,
BI3.10 / SLO 1. Mechanism of Blood Glucose Regulation 2. Interpretation of Laboratory investigations |
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| 80 | Regulation of Blood Glucose | Lecture | ||
| 81 | Diabetes mellitus | Lecture | ||
| 82 | Lab Diagnosis of Diabetes Mellitus | SGT | ||
| BI6.1 | Discuss
the metabolic processes that take place in specific organs in the body in the fed and fasting states. |
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| BI6.1
/SLO 1. Metabolism of Fed State 2. Metabolism of Fasting State |
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| 83 | Metabolism in Fed and Fasting states | SDL | ||
| 84,85 | Estimation of Glucose | Practical | ||
| 5 | Topic: Chemistry and Metabolism of Proteins | |||
| BI5.1 | Describe and discuss structural organization of proteins. | |||
| BI5.1
/ SLO 1. Primary Structure 2. Secondary Structure 3. Tertiary Structure 4. Quaternary Structure |
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| 86 | Chemistry Of Aminoacids | Lecture | ||
| BI5.3 | Describe the digestion and absorption of dietary proteins. | |||
| BI5.3
/ SLO 1. Mechanism of Digestion 2. Mechanism of Absorption 3. Disorders |
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| 87 | Digestion and Absorption of Protein | Lecture | ||
| BI5.4 BI5.5 |
Describe
common disorders associated with protein metabolism. Interpret laboratory results of analytes associated with metabolism of proteins. |
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| BI5.4,
BI5.5 / SLO 1. Definition 2. Metabolic Pathway 3. Regulation 4. Compounds Derived and its Role 5. Disorders |
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| 88 | Ammonia Metabolism | Lecture | ||
| 89 | Urea Cycle & its Disorder | Lecture | ||
| 90 | Glycine and Serine | Lecture | ||
| 91 | Alanine, Threonine, Glutamic Acid, | Lecture | ||
| 92 | Glutamine Aspartic Acid, Asparagine. | Lecture | ||
| 93 | Sulphur Containing Amino Acids | Lecture | ||
| 94 | Arginine. Nitric oxide. Lysine | Lecture | ||
| 95 | Polyamines & Branched Chain Amino Acid | Lecture | ||
| 96 | Phenyl Alanine, Tyrosine | Lecture | ||
| 97 | Tryptophan | Lecture | ||
| 98 | Histidine & Proline, One Carbon Metabolism | Lecture | ||
| 99 | Prenatal Screcning | Lecture | ||
| 100 | Disorders of Urea Cycle | SDL | ||
| 101 | Micro
albuminuria |
SGT | ||
| 102 | New born Screening | SGT | ||
| BI6.13 BI6.14 BI6.15 BI11.17 BI11.22 |
Describe
the functions of the kidney, liver, thyroid and adrenal glands. Describe the tests that are commonly done in clinical practice to assess the functions of these organs (kidney, liver, thyroid and adrenal glands). Describe the abnormalities of kidney, liver, thyroid and adrenal glands. Explain the basis and rationale of biochemical tests done in the following conditions: - diabetes mellitus, - dyslipidemia, - myocardial infarction, - renal failure, gout, - proteinuria, - nephrotic syndrome, - edema, - jaundice, - liver diseases, pancreatitis, disorders of acid- base balance, - thyroid disorders. Calculate albumin: globulin (AG) ratio and creatinine clearance |
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| BI6.13,
BI6.14, BI6.15, BI11.17, BI11.22 / SLO 1. Functions of Kidney 2. Renal diseases 3. Interpretation of Renal Function Test 4. Interpretation of Analysis of Abnormal Constituents in Urine |
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| 103 | Renal Function Test | Lecture | ||
| 104,105 | Describe & discuss Renal Function tests | IT | ||
| 106,107 | Physical & Microscopic Examination of Urine | Practical | ||
| 108,109 | Chemical Analysis of Urine | Practical | ||
| 110,111 | Analysis of Glucose and Ketone Bodies in Urine | Practical | ||
| 112,113 | Analysis of Protein & Blood in Urine | Practical | ||
| 114,115 | Analysis of Bile salt & Bile pigment in Urine | Practical | ||
| 116,117 | Estimation of Urea & Urea Clearance | Practical | ||
| 118,119 | Estimation of Creatinine & Creatinine Clearance | Practical | ||
| 120,121 | Estimation of Total Protein | Practical | ||
| 122,123 | Estimation of Albumin | Practical | ||
| 124,125 | Analysis of Non Protein Nitrogen Substances in Urine | Practical | ||
| BI6.13 BI6.14 BI6.15 |
Describe
the functions of the kidney, liver, thyroid and adrenal glands. Describe the tests that are commonly done in clinical practice to assess the functions of these organs (kidney, liver, thyroid and adrenal glands). Describe the abnormalities of kidney, liver, thyroid and adrenal glands. |
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| BI6.13,
BI6.14, BI6.15 / SLO 1. Mechanism of Action of Hormones 2. Biochemical and Physiological role of Hormones 3. Function of Thyroid and Adrenal Gland 4. Disorders 5. Interpretation of Thyroid and Adrenal Function Test |
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| 126 | Biosynthesis of Gonadal Hormones | Lecture | ||
| 127 | Mechanism of Hormones | Lecture | ||
| 128 | Mechanism of Action of Hormones | SDL | ||
| 129 | Interpretation of Thyroid and Adrenal Functions | SDL | ||
| 130,131 | Describe
function tests: Thyroid gland; Adrenal
cortex, Adrenal medulla and pancreas |
IT | ||
| BI6.13 BI11.17 |
Describe
the functions of the kidney, liver, thyroid and adrenal glands. Explain the basis and rationale of biochemical tests done in the following conditions: - diabetes mellitus, - dyslipidemia, - myocardial infarction, - renal failure, gout, - proteinuria, - nephrotic syndrome, - edema, - jaundice, - liver diseases, pancreatitis, disorders of acid- base balance, - thyroid disorders. |
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| BI6.13,
BI11.17 / SLO 1. Function of Thyroid and Pancreatic Gland 2. Disorders 3. Interpretation of Thyroid and Pancreatic Function Test 4. Interpretation of Gastric Function Test |
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| 132 | Thyroid & Pancreatic Function Test | Lecture | ||
| 133 | Gastric Function Test | SGT | ||
| 134,135 | Demonstration of Thyroid Function Test | Practical | ||
| 136 | Regulation
of Blood Glucose |
SGT | ||
| 6 | Topic: Chemistry and Metabolism of Lipids | |||
| BI4.1 BI11.24 |
Describe and
discuss main classes of lipids (Essential/non-essential fatty acids, cholesterol and hormonal steroids, triglycerides, major phospholipids and sphingolipids) relevant to human system and their major functions. Enumerate advantages and/or disadvantages of use of unsaturated, saturated and trans fats in food. |
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| BI4.1,
BI11.24 / SLO 1. Definition 2. Classification 3. Structure and Properties 4. Biological role of Lipids |
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| 137 | Chemistry of Lipids - I | Lecture | ||
| 138 | Chemistry of Lipids - II | Lecture | ||
| BI4.2 | Describe
the processes involved in digestion and absorption of dietary lipids and also the key features of their metabolism |
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| BI4.2
/ SLO 1. Mechanism of Digestion 2. Mechanism of Absorption 3. Disorders |
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| 139 | Digestion and Absorption of lipids | Lecture | ||
| 140 | β - Oxidation of Fatty Acids | Lecture | ||
| 141 | Fatty Acid Synthesis | Lecture | ||
| 142 | Synthesis Triglyceride | Lecture | ||
| 143 | Metabolism of Ketonebodies | Lecture | ||
| 144 | Cholesterol Metabolism | Lecture | ||
| 145 | Bile Acid Metabolism | Lecture | ||
| BI4.3 BI4.4 BI4.5 BI4.6 BI4.7 |
Explain
the regulation of lipoprotein metabolism & associated disorders. Describe the structure and functions of lipoproteins, their functions, interrelations & relations with atherosclerosis Interpret laboratory results of analytes associated with metabolism of lipids Describe the therapeutic uses of prostaglandins and inhibitors of eicosanoid synthesis. Interpret laboratory results of analytes associated with metabolism of lipids. |
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| BI4.3,
BI4.4, BI4.5, BI4.6, BI4.7 / SLO 1. Definition 2. Metabolic Pathway 3. Regulation 4. Disorders |
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| 146 | Lipoprotein Metabolism and Disorders | Lecture | ||
| 147 | Metabolism of Compound Lipids | Lecture | ||
| 148 | Prostaglandins | Lecture | ||
| 149 | Atherosceleorosis and Cardiac Markers | Lecture | ||
| 150 | Hyper Lipoproteinemia | SDL | ||
| 151 | Lipoprotein Metabolism | SGT | ||
| 152 | Interpretation of Lipid Profile | SGT | ||
| 153 | Adipose tissue Metabolism | SGT | ||
| 154 | Prostaglandins | SGT | ||
| 155,156 | Estimation of Serum Cholesterol | Practical | ||
| 157,158 | Estimation of Serum Triglyceride | Practical | ||
| 159,160 | Demonstration of Serum HDL | Practical | ||
| 161,162 | Discuss
and describe the lipid cycle and the role of dyslipidemia in the pathogenesis
of atherosclerosis Discuss and describe the indicatons, formulations, doses, side effects and monitoring for drugs used in the management of dyslipidemia |
IT | ||
| BI6.6 | Describe
the biochemical processes involved in generation of energy in cells. |
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| BI6.6
/ SLO 1. Definition 2. Components of ETC 3. Chemiosmotic Theory 4. Inhibitors of ETC 5. Uncouplers |
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| 163 | Electron Transport Chain | Lecture | ||
| 164 | Electron Transport Chain | SGT | ||
| BI6.7 BI6.8 BI11.2 |
Describe
the processes involved in maintenance of normal pH, water & electrolyte balance of body fluids and the derangements associated with these. Discuss and interpret results of Arterial Blood Gas (ABG) analysis in various disorders. Describe the preparation of buffers and estimation of pH. |
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| BI6.7,
BI6.8, BI11.2 / SLO 1. Definition 2. Buffer System 3. Regulation of Acid Base Balance 4. Anion Gap 5. Imbalance of Acid-Base Homeostasis |
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| 165 | Acid Base Balance | Lecture | ||
| 166 | Acid Base Disorders | Lecture | ||
| 167 | Interpretation of Acid base disorders | SDL | ||
| 168 | Regulation of Blood pH | SGT | ||
| 169 | ABG Analysis in Various Diseases | SGT | ||
| BI7.6 BI7.7 |
Describe
the anti-oxidant defence systems in the body. Describe the role of oxidative stress in the pathogenesis of conditions such as cancer, complications of diabetes mellitus and atherosclerosis. |
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| BI7.6, BI7.7 / SLO 1. Free Radicals 2. Mechanism of Action of ROS 3. Scavenger System 4. Role of Antioxidants |
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| 170 | Free Radicals and Anti-Oxidant | Lecture | ||
| 171 | Antioxidant
defence system |
SGT | ||
| 172 | Role of Oxidative stress in various disease | SDL | ||
| BI7.5 | Describe the role of xenobiotics in disease | |||
| BI7.5
/ SLO 1. Definition 2. Phases of Detoxicification 3. Role of xenobiotics in disease |
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| 173 | Xenobiotics | Lecture | ||
| 174 | Heavy Metal Poisoning | SDL | ||
| 7 | Nutrition | |||
| BI8.1 | Discuss the
importance of various dietary components and explain importance of dietary fibre. |
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| BI8.1
/ SLO 1. Definition 2. Sources 3. Biological role of Dietary Fibre |
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| 175 | Dietary fibre | Lecture | ||
| 176 | Dietary habits and its Nutritional Importances | SDL | ||
| BI8.2 BI8.3 |
Describe
the types and causes of protein energy malnutrition and its effects. Provide dietary advice for optimal health in childhood and adult, in disease conditions like diabetes mellitus, coronary artery disease and in pregnancy. |
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| BI8.2,
BI8.3 / SLO 1. Definition 2. Classification 3. Etio-pathogenesis 4. Clinical Features 5. Management |
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| 177 | Protein energy malnutrition | Lecture | ||
| 178 | Protein energy malnutrition and its effects. | SDL | ||
| 179,180 | Define
Describe the etio-pathogenesis, Classify including WHO classification, clinical features, complication and management of Severe Acute Malnourishment (SAM) and Moderate Acute Malnutrition (MAM) |
IT | ||
| BI8.4 BI8.5 |
Describe
the causes (including dietary habits), effects and health risks associated with being overweight/ obesity. Summarize the nutritional importance of commonly used items of food including fruits and vegetables. (macro-molecules & its importance) |
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| BI8.4,
BI8.5 / SLO 1. Definition 2. Causes 3 Regulation of Obesity 4. Assessment 5. Management |
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| 181 | Obesity | Lecture | ||
| 182 | Metabolic syndrome | SGT | ||
| BI11.23 | Calculate
energy content of different food Items, identify food items with high and low glycemic index and explain the importance of these in the diet |
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| BI11.23
/SLO 1. Definition 2. Factors affecting 3. Glycemic Index |
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| 183 | Specific Dynamic action, BMR & Glycemic index | Lecture | ||
| 184 | Glycemic index of food items | SDL | ||
| 8 | Molecular Biology | |||
| BI7.1 | Describe the
structure and functions of DNA and RNA and outline the cell cycle. |
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| BI7.1
/ SLO 1. Structure of DNA and RNA 2.Functions of DNA and RNA 3. Cell Cycle |
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| 185 | Structure and functions of DNA and RNA | Lecture | ||
| 186 | Cell cycle. | Lecture | ||
| BI6.2 BI6.3 BI6.4 |
Describe
and discuss the metabolic processes in which nucleotides are involved. Describe the common disorders associated with nucleotide metabolism. Discuss the laboratory results of analytes associated with gout & Lesch Nyhan syndrome. |
|||
| BI6.2,
BI6.3, BI6.4 / SLO 1. Metabolic process of Nucleotides 2. Inhibitors of Nucleotides 3. Disorders |
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| 187 | Purine Metabolism and Gout | Lecture | ||
| 188 | Pyrimidine Metabolism | Lecture | ||
| 189 | Gout | SGT | ||
| 190 | Analogues of Purine And Pyrimidine | SDL | ||
| 191,192 | Estimation of Uric Acid | Practical | ||
| BI7.2 BI9.3 |
Describe
the processes involved in replication & repair of DNA and the transcription & translation mechanisms. Describe protein targeting & sorting along with its associated disorders. |
|||
| BI7.2,
BI9.3 / SLO 1. Definition 2. Central Dogma of Molecular biology 3. Inhibitors 4. Associated Disorders |
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| 193 | DNA Replication | Lecture | ||
| 194 | DNA Damage and Repair | Lecture | ||
| 195 | Transcription | Lecture | ||
| 196 | Post - Transcriptional Modification | Lecture | ||
| 197 | Translation | Lecture | ||
| 198 | Post - Translation Modification and Protein Targeting | Lecture | ||
| 199 | Inhibitors of Replication, Transcription & Translation | SGT | ||
| 200 | Disorders
Associated with DNA damage and repair Mechanism |
SDL | ||
| 201 | Protein Targeting and its disorders | SGT | ||
| BI7.3 | Describe
gene mutations and basic mechanism of regulation of gene expression. |
|||
| BI7.3
/ SLO 1. Gene mutations 2. Mechanism of Regulation of Gene Expression. |
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| 202 | Regulation of Gene expression. | Lecture | ||
| BI7.4 | Describe
applications of molecular technologies like recombinant DNA technology, PCR in the diagnosis and treatment of diseases with genetic basis. |
|||
| BI7.4
/ SLO 1. Principles 2. Molecular Techniques 3. Applications |
||||
| 203 | Polymerisation chain Reaction & RFLP | Lecture | ||
| 204 | Recombinant DNA Technology | Lecture | ||
| 205 | Gene Therapy | Lecture | ||
| 206 | Blotting Techniques | Lecture | ||
| 207 | DNA Sequencing | Lecture | ||
| 208 | DNA finger printing and its application | SDL | ||
| 9 | Oncogenesis & immunity | |||
| BI10.1 BI10.2 |
Describe the
cancer initiation, promotion oncogenes & oncogene activation. Also focus on p53 & apoptosis Describe various biochemical tumor markers and the biochemical basis of cancer therapy. |
|||
| BI10.1,
BI10.2 / SLO 1. Definition 2. Biochemical Basis of Cancer 3. Tumor Markers 4. Cancer Therapy |
||||
| 209 | Biochemical basis of cancer and tumor markers | Lecture | ||
| 210 | Tumor Markers | SGT | ||
| 211 | Apoptosis | SGT | ||
| 212 | Anti cancer therapy | SGT | ||
| 213,214 | Describe
the clinical epidemiology and inherited assessment risk factors for common malignancies in India |
IT | ||
| BI10.3 BI10.4 BI10.5 |
Describe
the cellular and humoral components of the immune system & describe the types and structure of antibody Describe & discuss innate and adaptive immune responses, self/non-self recognition and the central role of T-helper cells in immune responses. Describe antigens and concepts involved in vaccine development. |
|||
| BI10.3,
BI10.4, BI10.5 / SLO 1. Definition 2. Classification 3. Structure and its Function 4. Immunoglobinopathies |
||||
| 215 | Structure of Immunoglobins and its Types | Lecture | ||
| 216 | Immunoglobinopathies | SGT | ||
| 10 | Extra Cellular Matrix | |||
| BI9.1 BI9.2 |
List the
functions and components of the extracellular matrix (ECM). Discuss the involvement of ECM components in health and disease. |
|||
| BI9.1,
BI9.2 / SLO 1. Components of ECM 2. Functions 3. Role of ECM in Health and Disease |
||||
| 217 | Extra
Cellular Components in Health and Disease and Collagen (ECM) |
Lecture | ||
| 218 | Collagen disorders | SGT | ||
| 219 | Plasma Proteins | Lecture | ||
| 220,221 | Demonestration Separation of serum Proteins by Electrophoresis | Practical | ||
| 11 | Biochemical Laboratory Tests | |||
| BI11.18 BI11.19 |
Discuss the
principles of spectrophotometry. Outline the basic principles involved in the functioning of instruments commonly used in a biochemistry laboratory and their applications. |
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| BI11.18,
BI11.19 / SLO 1. Definition 2. Principles 3. Procedure 4. Applications |
||||
| 222 | Spectophotometry
and Colorimetry and its Application |
Lecture | ||
| BI11.5 BI11.16 |
Describe
screening of urine for inborn errors & describe the use of paper chromatography Observe use of commonly used equipments/techniques in biochemistry laboratory including: •pH meter •Paper chromatography of amino acid •Protein electrophoresis •TLC, PAGE •Electrolyte analysis by ISE •ABG analyzer •ELISA •Immunodiffusion •Autoanalyser •Quality control •DNA isolation from blood/ tissue |
|||
| BI11.5,
BI11.16 / SLO 1. Definition 2. Principles 3. Procedure 4. Applications |
||||
| 223 | ELISA and RIA | Lecture | ||
| 224 | Chromatography | Lecture | ||
| 225 | Applications of Chromatography | SDL | ||
| 226,227 | Demonstration of Separation of Amino acids by Paper Chromatography | Practical | ||
| 228,229 | Demonstration of Auto Analyzer | Practical | ||
| BI11.15 | Describe & discuss the composition of CSF | |||
| BI11.15
/ SLO 1. Composition of Body Fluids 2. Interpretation of CSF Analysis |
||||
| 230 | Body Fluids | Lecture | ||
| 231 | CSF Analysis | SGT | ||
| 232,233 | Demonstration of Glucometer | Practical | ||